Abstract
The human brain gives rise to a great variety of conscious experiences. Patients with disorders of consciousness, a state characterized by the dissociation of awareness and wakefulness, are particularly noteworthy. This study attempts to find key biomarkers of the disorder of consciousness state and discover key regions of the brain that govern consciousness. The focus is on the ascending arousal network—a network of nodes and edges representing connections from the brainstem to subcortical (thalamus, hypothalamus, basal forebrain) nuclei and reaching the cerebral cortex. Previous studies using animal models have demonstrated a high prognostic value of the ascending arousal network in relation to consciousness. This study conducts a diffusion tensor imaging analysis and generates a tract count plot to illustrate differences in connectivity between (N=6) healthy controls and (N=6) patients with chronic disorders of consciousness. Each region of interest was isolated to investigate its specific role and impact on consciousness. A principal component analysis was performed to assess the separability of the two cohorts. The results found each of the regions of interest to be significantly (p<0.05) disrupted in patients with disorders of consciousness. They contributed equally to the linear separability of the two cohorts. This is consistent with previous research and hints at the importance of the ascending arousal network in governing consciousness. These changes are likely associated with the many pathological deteriorations associated with an impaired cognitive state, such as neuronal loss, gliosis, and the degeneration of white matter tracts that connect critical areas of the brain involved in consciousness.

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