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Schizophrenia is classified as one of the most debilitating mental health disorders due to the chronicity of symptoms and the magnitude of impairments in multiple domains of the individual’s life (Shetty & Bose, 2014). Research has consistently demonstrated that Black Americans, in comparison to other racial groups, have the highest prevalence rates of schizophrenia. With a paucity of empirical evidence ascertaining the etiology of schizophrenia, many scholars assert that elevated levels of stress play a critical role in the development of the disorder. This paper draws uponthe diathesis-stress model to elucidate a relationship between signi cantlevels of stress endured by Black Americans due to racism and their elevated rates of schizophrenia. The presented argument calls for further research on the impact of racism on Black Americans’ disproportionately high rates of schizophrenia diagnoses.